Sulfaprim is an antibacterial drug where sulfamerazine and trimethoprim are active ingredients.

Sulfaprim is produced in the form of powder, granules and tablets. The drug by its appearance is a water-soluble uniform crystalline powder white to cream color or granules of various shapes white to cream color or tablets of round shape white or white with yellow shading.One gram of drug in the form of powder or granule contains 0.12 g active substance, (0.1 g sulfamerazine and 0.02 g trimethoprim).

The drug is pre-packaged: powder and granules in double package made of polyethylene film or polymer bags by 0.2; 0.3; 0.5; 1,0; 2.0 kg; tablets – in opaque polymer pots by 50, 100, 250, 500, 1,000 tablets or in blisters from composite materials by 10-50 pcs.
The drug should be stored with caution (see List B ) in a dry, dark place within the temperature range from 0ºC to +25ºC Shelf life is 2 years under specified storage conditions.  

included in the drug have a synergistic effect and determine its high antimicrobial
activity. The drug suppresses development of many Gram-positive and Gram-negative microorganisms, including Salmonella, Pasteurella, Escherichia, but it is not active against fungi and viruses.

Drug affects folic acid biosynthesis in microorganisms.

After oral administration the drug is quickly absorbed by gastrointestinal tract and is penetrated through organs and tissues and it has bactericidal effect. Maximum concentration in blood is reached 2-4 hours after drug administration. Therapeutic concentration in blood retains for 12 hours. The drug is eliminated mainly with urine.

The drug is administered orally 4-6 days 2 times a day based on 5 g powder or granules per 20 kg of animal weight or 30 mg active substance per 1 kg.
During treatment animals shall be provided with free access to water.

Birds are prescribed 1.0 g per 5 kg feed 2 times a day with 12 hours interval within 3-5 days. Sulfaprim may be used in combination with antibiotics. In such cases antimicrobial spectrum and therapeutic properties shall be substantially increased.

Sulfaprim is used in young animals against pneumonia, catarrhal pneumonia, bronchitis, laryngitis, tonsillitis, sepsis, necrobacillosis in sheep and reindeers, dyspepsia, gastroenteritis, urinary tract infections, salmonellosis, pasteurellosis, respiratory mycoplasmosis, eimeriosis in poultry and other diseases, which pathogens are sensitive to the drug components.

Side effects at recommended dosages as a rule are not observed. Loss of appetite, diarrhea and vomiting may be observed if animals have individual hypersensitivity to sulfonamides. In such cases use of drug should be discontinued.

CONTRAINDICATIONS: Application of sulfaprim shall be contraindicated at blood diseases, acute hepatitis, nephritis and hypersensitivity to the drug components. It is forbidden to use this drug in milking animals.

Slaughtering of animals for meat shall be allowed 7 days, and poultry 12 days after the last drug administration. Meat of animals during urgent slaughter before expiry
of specified period shall be used to feed flesh eaters or for production of meat and bone meal tankage. Milk shall be allowed for consumption to humans not earlier than four days after the last drug administration. Before expiry of specified period such milk can be used for feeding animals after boiling.